Mitra, I., Potes, M. A., Shafi, M., Tilton, M., Elder, B. D., & Lu, L. · Biomaterials Advances · 2025
There is a significant clinical need to develop effective treatments for bone defects in patients with diabetes mellitus (DM), as they are at higher risk of fractures and impaired healing.
Guided bone tissue engineering using biocompatible and biodegradable polymers is a promising approach.
However, current diabetic bone regenerative therapies often fail due to the accumulation of advanced glycation products..
Potes, M.A., Tilton, M., Mitra, I., Liu, X., Dashtdar, B., Camilleri, E.T., Elder, B.D. and Lu, L. · International Journal of Extreme Manufacturing · 2024
Degenerative spine pathologies, including intervertebral disc (IVD) degeneration, present a significant healthcare challenge due to their association with chronic pain and disability.
This study explores an innovative approach to IVD regeneration utilizing 3D bioprinting technology, specifically visible light-based digital light processing, to fabricate tissue scaffolds that closely mimic the native architecture of the IVD.
Potes, M.A., Mitra, I., Hanson, K., Camilleri, E.T., Gaihre, B., Shafi, M., Hamouda, A., Lu, L. and Elder, B.D. · Journal of Orthopedic Research · 2024
Segmental bone defects, often clinically treated with nondegradable poly(methylmethacrylate) (PMMA) in multistage surgeries, present a significant clinical challenge.
Our study investigated the efficacy of 3D printed biodegradable polycaprolactone fumarate (PCLF)/PCL spacers in a one‐stage surgical intervention for these defects, focusing on early bone regeneration influenced by spacer porosities.
Bandyopadhyay, A., Mitra, I., Ciliveri, S., Avila, J. D., Dernell, W., Goodman, S. B., & Bose, S. · International Journal of Extreme Manufacturing · 2023
Bacterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-bearing metallic implants.
Topical or systemic administration of antibiotics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limbs.
Bandyopadhyay, A., Mitra, I., Avila, J. D., Upadhyayula, M., & Bose, S. · International Journal of Extreme Manufacturing · 2023
Porous and functionally graded materials have seen extensive applications in modern biomedical devices—allowing for improved site-specific performance;
their appreciable mechanical, corrosive, and biocompatible properties are highly sought after for lightweight and high-strength load-bearing orthopedic and dental implants.
Bandyopadhyay, A., Mitra, I., Goodman, S. B., Kumar, M., & Bose, S. · Progress in materials science · 2023
The increasing need for joint replacement surgeries, musculoskeletal repairs, and orthodontics worldwide prompts emerging technologies to evolve with healthcare's changing landscape.
Metallic orthopaedic materials have a shared application history with the aerospace industry, making them only partly efficient in the biomedical domain.
However, suitability of metallic materials in bone tissue replacements and regenerative therapies remains unchallenged due to their superior mechanical properties, eventhough they are not perfectly biocompatible.
Ciliveri, S., Mitra, I., Bose, S., Bandyopadhyay, A. · Metal-Matrix Composites. The Minerals, Metals & Materials Series · 2022
Titanium and its alloys are known for their excellent biocompatibility and mechanical performance and are used widely in load-bearing implant applications.
However, titanium is bioinert, i.e., it does not help in bone–tissue interactions, thus not aiding in expedited patient healing.
The inorganic phase of the bone contains macro-nutrients in trace elements such as Mg2+, Si4+, which play a vital role in bone formation and remodeling.
Mitra, I., Bose, S., Dernell, W.S., Dasgupta, N., Eckstrand, C., Herrick, J., Yaszemski, M.J., Goodman, S.B. and Bandyopadhyay, A. · Materials today · 2021
3D Printing (3DP) or additive manufacturing (AM) enables parts with complex shapes, design flexibility, and customization opportunities for defect specific patient-matched implants.
3DP or AM also offers a design platform that can be used to innovate novel alloys for application-specific compositional modifications.
In medical applications, the biological response from a host tissue depends on a biomaterial's structural and compositional properties in the physiological environment.
Bandyopadhyay, A., Mitra, I. & Bose, S. · Current Osteoporosis Reports · 2020
Three-dimensional printing (3DP) or additive manufacturing (AM) has transformed the manufacturing world in the past three decades—from product design/concept models to rapid prototyping and functional part manufacturing.
3DP is a layer-by-layer process that allows us to manufacture complex structures without any part-specific tooling.
The first commercial 3DP technology, called “stereolithography,” was introduced by Charles Hull in 1988. Since then, different 3DP processes have been introduced commercially for a variety of materials and applications..
Bandyopadhyay, A., Shivaram, A., Mitra, I., & Bose, S. · Acta biomaterialia · 2019
Ti is characteristically bioinert and is supplemented with modifications in surface topography and chemistry to find use in biomedical applications.
The aim of this study is to understand the effects of surface charge on TiO2 nanotubes (TNT) on Ti implants towards early stage osseointegration.
Bandyopadhyay, A., Mitra, I., Shivaram, A., Dasgupta, N., & Bose, S. · Additive Manufacturing · 2019
Material properties of implants such as volume porosity and nanoscale surface modification have been shown to enhance cell-material interactions in vitro and osseointegration in vivo.
Porous tantalum (Ta) and titanium (Ti) coatings are widely used for non-cemented implants, which are fabricated using different processing routes.
In recent years, some of those implants are being manufactured using additive manufacturing.
Mitra, I., Manna, N., Manna, J. S., & Mitra, M. K. · Procedia Materials Science · 2014
A class of luminescent porous, spherical silica nanoparticles have been synthesized using simple oil-in-water microemulsion process in the size range of 15-50 nm evident from TEM and FESEM analysis.
Mechanism of successful stabilization of chlorophyll molecule inside the nanoparticles has been evaluated by FTIR studies, and also supported by UV-Vis spectra.